In order to investigate the hypothetic defense mechanism of essential metals which take part in the healing process of bone fracture, the author measured the changes of whole blood concentration of Ca, Mg, Zn and Cu from 88 fractured patients as
experimental group, and 49 healthy, male medical students as control group, using Inductively Coupled Plasma Emission Spectrometer.
@ES The obtained results were as follows.
@EN 1. The mean concentrations of Ca at the time of fracture, at 1 month after fracture and at 3 months after fracture were 52.55±17.37g/ml, 60.45±14.37g/ml and 65.33±16.73g/ml, respectively and increased significantly through the healing
process of
bone fracture(p<0.05). The Ca concentration of fracture group at 3 months was higher than that of control.
2. The mean concentrations of Mg at the time of fracture, at 1 month and at 3 months were 26.50 6.76g/ml, 28.46±6.11g/me, 29.51±4.32g/ml, respectively and increased significantly through the healing process(p<0.05). The concentration of Mg in
fracture group were lower than that of control(p<0.05).
3. The mean concentration of Zn at the time of fracture, at 1 month and at 3 months were 6.73±1.68g/ml, 6.48±1.25g/ml, 6.91±1.58g/ml, respectively and the changing tendencies were not statistically significant through the healing
process(p>0.05).
The concentration of Zn in fracture group were lower than that of control.
4. The mean concentrations of Cu at the time of fracture, at 1 month and at 3 months were 1.04±0.38g/ml, 1.11±0.46g/ml, 1.13±0.42g/ml, respectively and increased and increased through the healing process, but the changes were not
statistically
significant(p>0.05). The concentrations of Cu in fracture group were higher than that of control(p<0.05).
5. There were positive correlations between Ca and Mg. Zn and Cu concentration (P<0.01) in both fracture and control groups, but no constant correlations were found in the other metals.
6. The ratio of Mg/Ca was tend to decrease through the healing process of bone fracture, but the ratio of Zn/Cu was showed no constant change in fracture group and that was higher in control(p<0.05).
7. As above results, the changes of essential metal(Ca, Mg, Zn, Cu) concentrations in whole blood have meaningful role in healing process of bone fracture.
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